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By J. Smith
J. Smith
Articles
12 January 2026
Last Updated: 12 January 2026
Hits: 54
  • Type 2 Diabetes
  • Juleen Zierath
  • Exercise and Metabolism
  • Insulin Resistance
  • Skeletal Muscle

Professor Juleen R. Zierath: Three Decades of Showing How Exercise Changes Metabolism

Photo by Ricky Molloy. Courtesy of Novo Nordisk Foundation.

A look at the science that explains why exercise improves glucose regulation even when insulin cannot.

Abstract

Professor Juleen R. Zierath has spent more than three decades uncovering how exercise reshapes muscle metabolism and why these mechanisms matter for people with obesity or type 2 diabetes. Her work demonstrates that insulin resistance originates in skeletal muscle and that exercise can bypass this defect through alternative pathways that enhance glucose uptake. By connecting molecular biology, circadian timing, gene regulation, and real-world physiology, she has built a foundation for more personalized approaches to metabolic health. Her research offers insight into why movement remains one of the most effective tools for improving glucose regulation and overall metabolic function.

Key Points

  • Insulin resistance in type 2 diabetes occurs in the skeletal muscle, where defects in insulin signaling limit glucose uptake, making this tissue central to metabolic dysfunction.
  • Exercise bypasses impaired insulin pathways through contraction-driven mechanisms that activate AS160, AMPK, and GLUT4 movement, improving glucose uptake even when insulin is less effective.
  • Skeletal muscle is highly adaptable, and Zierath’s work shows how different types of training reshape fuel use, mitochondrial function, and long-term insulin sensitivity.
  • Epigenetic and circadian factors influence metabolic health, with exercise capable of modifying DNA methylation patterns and interacting with the body’s internal clocks to improve glucose control.
  • These insights point toward personalized exercise and nutrition strategies, grounded in genetics, timing, and individual metabolic responsiveness, rather than one-size-fits-all recommendations.

Read more: Professor Juleen R. Zierath: Three Decades of Showing How Exercise Changes Metabolism

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By J. Smith
J. Smith
Articles
11 January 2026
Last Updated: 11 January 2026
Hits: 65
  • Continuous Glucose Monitoring
  • Time in Range
  • Glucose Patterns
  • Diabetes Data Visualization
  • Emotional Impact of CGM

A More Human View of Glucose: How Hourly Visualizations Reduce Anxiety and Reveal Real Patterns

Hourly Time in Range (TIR)

Hourly glucose visualizations replace judgment with understanding by showing when patterns occur and reducing the emotional burden of daily performance scores.

Abstract

Continuous glucose monitoring provides valuable information, but traditional daily Time in Range summaries often create unnecessary emotional pressure. This article explores how hourly Time in Range and Coefficient of Variation visualizations offer a more supportive, more insightful way to understand glucose patterns. By focusing on timing, consistency, and possibility, these visualizations shift the experience from judgment to clarity and help people interpret their data with confidence.

Key Points

  • Daily percentages flatten important details and can feel like performance scores rather than meaningful descriptions of glucose patterns.
  • Hourly visualizations reveal timing, making it easier to understand post-meal spikes, overnight stability, and recurring trends.
  • Neutral design choices, including a green–blue color scale and multi-day aggregation, reduce judgment and lower emotional burden.
  • Perspectives from the diabetes community highlight the need for data tools that support understanding instead of creating guilt or anxiety.
  • Side-by-side views of time in range and variability help people and clinicians interpret patterns more effectively and focus on what is possible.

Read more: A More Human View of Glucose: How Hourly Visualizations Reduce Anxiety and Reveal Real Patterns

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By J. Smith
J. Smith
Articles
23 November 2025
Last Updated: 23 November 2025
Hits: 169
  • Wegovy
  • Obesity Treatment
  • GLP-1 Medicines
  • Drug Regulation
  • Medication Safety

Wegovy Will Not Go OTC: What the Sources Actually Say

Wegovy 2.4 mg Pens

A clear look at what Novo Nordisk actually said about Wegovy and why current GLP-1 therapies are not suited for OTC use.

Abstract

Discussion about Wegovy potentially moving to over-the-counter status has grown on social media, but the reporting does not support that interpretation. The statements from Novo Nordisk’s new board chair focus on strengthening consumer-oriented strategy, not pursuing OTC approval for GLP-1 therapies. This analysis reviews what was said, how it has been misinterpreted, and why current GLP-1 medications do not meet the safety, regulatory, or clinical requirements for OTC use.

Key Points

  • Official statements addressed board expertise, not an OTC pathway.
    The new chair emphasized interest in board members with OTC experience to support direct-to-consumer models, not to convert Wegovy to OTC status.
  • Social media amplified a speculative remark into an “inevitable” outcome.
    The reporting shows no regulatory plan, timeline, or active effort to make Wegovy an OTC product.
  • Current GLP-1 therapies cannot meet OTC safety standards.
    Injectable formulations require refrigeration, and both injectable and oral versions rely on mandatory dose escalation to manage side effects.
  • Unsupervised initiation poses clear clinical risks.
    Starting at a high dose without medical guidance increases the likelihood of severe nausea, dehydration, and other adverse events requiring medical attention.
  • GLP-1 medications treat chronic conditions requiring ongoing monitoring.
    Regulators expect screening and follow-up for this class, which creates built-in barriers to OTC approval.

Read more: Wegovy Will Not Go OTC: What the Sources Actually Say

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By J. Smith
J. Smith
Articles
14 September 2025
Last Updated: 14 September 2025
Hits: 79
  • Diabetes
  • CGM
  • Personalized Medicine
  • BGM
  • Healthcare Data

Bridging Data and Healthcare in the Nordics

Personalised Medicine from a Nordic Perspective

I completed Personalised Medicine from a Nordic Perspective through the University of Copenhagen and University of Iceland. The course explored how biobanks (collections of biological samples), health registries, and biomarkers (measurable health indicators) can be used to guide individual care, while also addressing risk communication, data protection, and broader ethical considerations.

People with diabetes often generate large amounts of data through continuous glucose monitors (CGMs), blood glucose meters (BGMs), and other wearables. This course highlights how similar kinds of data are used in healthcare systems to guide individual care, protect privacy, and support better outcomes. The material is presented in a way that makes these complex topics accessible to a broader audience, not just specialists.

This course was built and launched by two principal collaborators, Sisse Rye Ostrowski, MD, University of Copenhagen and Sædís Sævarsdóttir, MD, University of Iceland. They summed up its importance this way:

“The healthcare system is a wonderful place to be if you’re interested in data and developing algorithms. There are extremely complex data like omics data, register data, and data from wearables with all kinds of measurements you could possibly imagine. So, the healthcare field is the data playground of the future.” - Ostrowski

“We want people to understand the challenges involved and how collaboration and technological innovation is the key to shaping the future of healthcare.” - Sævarsdóttir

Explore the Course: Personalised Medicine from a Nordic Perspective

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Articles

  • Professor Juleen R. Zierath: Three Decades of Showing How Exercise Changes Metabolism
  • A More Human View of Glucose: How Hourly Visualizations Reduce Anxiety and Reveal Real Patterns
  • Wegovy Will Not Go OTC: What the Sources Actually Say
  • Bridging Data and Healthcare in the Nordics
  • How Well Do My CGM and BGM Readings Match?
  • Epigenetic Clues to Heart Risk in Type 2 Diabetes
  • Could a Gut Bacterium Help Transform Diabetes and Obesity Care?
  • Why mRNAs Are a Good Option for Vaccines
  • Why I Took Medical Courses to Strengthen My Data Skills
  • New Research Reveals the Hidden Complexity of Insulin Resistance
  • What the 2025 Diabetes Care Updates Mean for You
  • How an Hour-by-Hour View Transforms Time in Range Insights
  • Successfully Completed: Diabetes – A Global Challenge
  • Join the 5K@ADA Virtual Challenge to Promote Diabetes Awareness and Healthy Living
  • How Tirzepatide is Revolutionizing Type 2 Diabetes Prevention in Overweight and Obese Adults
  • Eli Lilly and Novo Nordisk Invest in Increased Manufacturing Capacity for GLP-1 Drugs
  • FDA Issues Alert on Compounded Semaglutide Dosing Errors
  • Join the 5K@EASD Virtual Challenge to Promote Diabetes Awareness and Healthy Living
  • Regulatory Hurdles for Awiqli: Approval in Canada and EU, Concerns in the US
  • Tirzepatide’s Efficacy in Treating Obstructive Sleep Apnea

News

January 2026

  • Wegovy Oral Pill Launches in United States

December 2025

  • FDA Approves First Oral GLP-1 for Chronic Weight Management
  • Retatrutide Delivers Phase 3 Success and Signals Lilly’s Strategic Positioning

November 2025

  • Novo Nordisk Seeks FDA Approval for Higher 7.2 mg Dose of Wegovy
  • Novo Nordisk Reports Strong Phase 2 Results for Amycretin in Type 2 Diabetes
  • Oral Semaglutide Does Not Slow Alzheimer’s Progression: How Today’s Results Fit the Larger Story
  • Zealand Pharma Pauses Development of Dapiglutide

October 2025

  • Innovent’s Mazdutide Outperforms Semaglutide in Head-to-Head Trial
  • Semaglutide’s Heart Benefits Extend Beyond Weight Loss
  • Terns Ends Development of Oral Obesity Drug After Phase 2 Results
  • FDA Approves Novo Nordisk’s Oral Semaglutide for Heart Protection in Type 2 Diabetes

Top Subjects

  • Type 2 Diabetes
  • Obesity Treatment
  • Semaglutide
  • Novo Nordisk
  • Wegovy
  • GLP-1
  • Eli Lilly
  • Tirzepatide
  • Continuous Glucose Monitoring
  • Oral Semaglutide
  • Clinical Trial Results
  • Ozempic
  • FDA Approval
  • Zepbound
  • GLP-1 Therapy
  • GLP-1 Medicines
  • Drug Regulation
  • Medication Safety
  • EVOKE Trials
  • Alzheimer’s Disease
  • Oral GLP-1 Therapy
  • Time in Range
  • Diabetes
  • Clinical Trials
  • Glucose Patterns
  • Diabetes Data Visualization
  • Emotional Impact of CGM
  • Obesity
  • Diabetes Management
  • Cardiovascular Health

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